lungs Aquilo

The PDE4 inhibitor CHF-6001 and LAMAs inhibit bronchoconstriction-induced remodeling in lung slices

Kistemaker LEM, Oenema TA, Baarsma HA, Bos IST, Schmidt M, Facchinetti…
lungs Aquilo

Elastase-Induced Parenchymal Disruption and Airway Hyper Responsiveness in Mouse Precision Cut Lung Slices: Toward an Ex vivo COPD Model

Van Dijk EM, Culha S, Menzen MH, Bidan CM & Gosens R. Front…
lungs Aquilo

HDAC-3 selective inhibitor RGFP966 demonstrates anti-inflammatory properties by attenuating NF-κB p65 transcriptional activity

Leus NG, van der Wouden PE, van den Bosch T, Hooghiemstra WT,…
lungs Aquilo

Combination therapy of tiotropium and ciclesonide attenuates airway inflammation and remodeling in a guinea pig model of chronic asthma

Kistemaker LEM, Bos IST, Menzen MH, Maarsingh H, Meurs H &…
lungs Aquilo

Anti-inflammatory effects of targeted lung denervation in patients with COPD.

Kistemaker LEM, Slebos DJ, Meurs H, Kerstjens HAM & Gosens…
lungs Aquilo

Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells.

Kistemaker LEM, Hiemstra PS, Bos IST, Bouwman S, van den Berge…
lungs Aquilo

Acetylcholine beyond bronchoconstriction: roles in inflammation and remodeling.

Kistemaker LEM & Gosens R. Trends Pharmacol Sci., 2015 Mar;36(3):164-71. …
lungs Aquilo

Muscarinic M3 receptors contribute to allergen-induced airway remodeling in mice.

Kistemaker LEM, Bos IST, Hylkema MN, Hiemstra PS, Wess J, Meurs…