ActinMouse models of asthma

Features:

  • Ovalbumin or house dust mite exposure
  • Airway eosinophilia, cytokine production,
  • Airway smooth muscle thickening,
  • Goblet cell hyperplasia,
  • Subepithelial fibrosis,
  • Pulmonary vascular remodeling.

PASWe have previously shown efficacy of anticholinergics, in particular M3 selective anticholinergics, in this model using C57Bl/6 mice. Both C57Bl/6 and Balb/c mice can be used. Balb/c mice have more profound eosinophilic inflammation, whereas the remodeling is comparable between these strains.

Previous publication

–        Kistemaker LEM, Bos IST, Hylkema MN, Hiemstra PS, Wess J, Meurs H, Kerstjens HAM & Gosens R. Muscarinic M3 Receptors Contribute to Allergen-induced Ariway Remodeling in Mice. Am J Respir Cell Mol Biol 2013.

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