FZ parenchymGuinea pig model of acute LPS exposure

Features:

  • Neutrophilic inflammation in the bronchoalveolar lavage fluid

We can test the effectiveness of your compound against this neutrophilic inflammation. We have previously demonstrated efficacy of anticholinergics and β2 agonists in this model.

 

Previous publication

–        Smit M, Zuidhof AB, Bos IST, Maarsingh H, Gosens R, Zaagsma J, Meurs H. Effects Of Olodaterol And Tiotropium On Lipopolysaccharide-Induced Airway Hyperresponsiveness And Inflammation. Am J Respir Crit Care Med 2013;187:A1955.

CollagenGuinea pig model of chronic LPS exposure

Features:

  • Twice weekly LPS challenges for 12 weeks,
  • Tissue neutrophilia and cytokine production,
  • Collagen deposition around the small airways,
  • Mucus gland hypertrophy, goblet cell hyperplasia,
  • Right ventricle remodeling.

We have previously shown efficacy of anticholinergics and GSK-3 inhibitors in this model.

Previous publications

–        Baarsma HA, Bos S, Meurs H, Visser KH, Smit M, Schols AM, Langen RC, Kerstjens HA, Gosens R. Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: I. Effects on lung remodeling and pathology. Respir Res. 2013;23;14:113.

–        Pera T, Zuidhof A, Valadas J, Smit M, Schoemaker RG, Gosens R, Maarsingh H, Zaagsma J, Meurs H. Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD. Eur Respir J 2011; 38:789-96.

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